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The impact of introducing a 2 step algorithm for diagnosis of C. diff
The Impact of Introducing a Two-Step Algorithm for Laboratory Diagnosis of C. difficile Infection
Jonathan Swindells, Richard Anderson and Beryl Oppenheim
Department of Microbiology, SWBH NHS Trust, Birmingham
In April 2009 our laboratory introduced a new two-step testing algorithm for C. difficile infection (CDI): initially, all liquid stool samples are screened for C. difficile antigen and toxins using the C. DIFF QUIK CHEK COMPLETE™ (Techlab) test. All antigen-positive samples then undergo polymerase chain reaction (PCR) using the Xpert™ C. difficile (Cepheid) platform to detect toxin B gene.
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